1.
Chinese Journal of Postgraduates of Medicine
;
(36)2006.
Article
in Chinese
| WPRIM
| ID: wpr-526763
ABSTRACT
Objective To investigate the role of islet B cell dysfunction in the pathogenesis of type 2 diabetes mellitus. Methods FBG and fasting plasma insulin of 49 healthy subjects and 125 first-degree relatives of type 2 diabetes mellitus were determined. HOMA model was used to calculate HOMAIR as an index of insulin resistance and HOMAB as an index of B cell function of pancreatic islet.The insulin sensitivity index(ISI) and early-stage secretion index of islet ?cell(△I_ 30 /△G_ 30 )were calculated. Results The HOMAB and △I_ 30 /△G_ 30 of the group of normal first-degree relatives were higher (P